ABSTRACT
The problem of the non-smooth course of COVID-19 and deaths in children with severe comorbid pathology is urgent. Among all registered cases of a new coronavirus infection in the Russian Federation, children account for up to 8,6%, of which severe forms are noted, as a rule, in patients with concomitant diseases. A clinical observation of the course of a new coronavirus infection in a child with a severe form of idiopathic aplastic anemia complicated by pancytopenia is presented. COVID-19 infection caused a sharp deterioration in the child's condition. Despite the use of modern methods of therapy, there was a rapid deterioration of clinical and laboratory parameters: an increase in febrility, respiratory failure, interstitial changes in the lungs, a decrease in oxygen saturation to 70%, hemorrhagic, anemic syndromes and multiple organ failure with the development of a fatal outcome. Aplastic anemia is a factor predisposing to the severe course of COVID-19 and contributing to an unfavorable outcome.Copyright © 2022 Interregional public organization Association of infectious disease specialists of Saint-Petersburg and Leningrad region (IPO AIDSSPbR). All rights reserved.
ABSTRACT
The problem of the non-smooth course of COVID-19 and deaths in children with severe comorbid pathology is urgent. Among all registered cases of a new coronavirus infection in the Russian Federation, children account for up to 8,6%, of which severe forms are noted, as a rule, in patients with concomitant diseases. A clinical observation of the course of a new coronavirus infection in a child with a severe form of idiopathic aplastic anemia complicated by pancytopenia is presented. COVID-19 infection caused a sharp deterioration in the child's condition. Despite the use of modern methods of therapy, there was a rapid deterioration of clinical and laboratory parameters: an increase in febrility, respiratory failure, interstitial changes in the lungs, a decrease in oxygen saturation to 70%, hemorrhagic, anemic syndromes and multiple organ failure with the development of a fatal outcome. Aplastic anemia is a factor predisposing to the severe course of COVID-19 and contributing to an unfavorable outcome.Copyright © 2022 Interregional public organization Association of infectious disease specialists of Saint-Petersburg and Leningrad region (IPO AIDSSPbR). All rights reserved.
ABSTRACT
According to the available data, children are less susceptible for developing a severe course of COVID-19 and commonly have mild or asymptomatic course of infection. It is reported about an increased risk of having more severe course in infants, at the same time, according to the literature data, the course in children receiving antineoplastic and immunosuppressive therapy is milder in comparison with other concomitant pathologies. This article presents the unique clinical case and the literature review of combined COVID-19-pneumonia and extremely rare congenital myeloid leukemia in the infant with the description of long-term infection persistence, changes in clinical data in dynamics, bone marrow test results and the experience of using donor plasma with antibodies to SARS-CoV-2. © 2022, Graphica Ltd. All rights reserved.
ABSTRACT
To assess the state of children’s health in obstetric care organizations after Russia transition to international statistics on live births and stillbirths, we studied the main indicators of newborn health in the dynamics from 2013 to 2020. It was found that between 2013 and 2020 the morbidity of newborns decreased by 6.3% (from 337.2‰ to 316.3‰;p<0.05), neonatal mortality by 45.7% (from 3.5‰ to 1.9‰;p<0.05), stillbirth rate by 45.6% (from 10.9‰ to 5.5‰;p<0.05), and hospital mortality of newborns born sick and ill by 40.0% (from 1.0% to 0.6%;p<0.05). Assessment of the distribution of live-born infants by birth weight showed that changes in this parameter of physical development during the period under study had no statistically significant differences (p>0.05). The assessment of the impact of the COVID-19 pandemic on newborn health revealed slight shifts in the distribution of children born alive by birth weight and a 6.8% increase in the stillbirth rate compared to the pre-pandemic level. Thus, in the period from 2013 to 2020 the share of children discharged from obstetric hospitals who were healthy has increased due to the reduction in morbidity and mortality of newborns. The analysis showed that there was an improvement in the health indicators of newborns in the Russian Federation.
ABSTRACT
In the Russian Federation, the proportion of children among all cases of new coronavirus infection is up to 8.6%. Mild forms are registered in 80% of cases, severe – 0.2%, as a rule, in children of the first year of life. The majority of deaths were recorded in children with an unfavorable background:75% of those who died had one concomitant pathology, 45% – two or more. The problem of severe course and fatal outcomes from COVID-19 in children with comorbid pathology, for example, with various forms of leukemia, remains relevant. Severe infectious complications of bacterial nature are observed in 70–80% of sick children, viral and fungal genesis, respectively, in 4–12% and 18–20%. Myeloblastic leukemia is one of the factors that predispose to a severe course of COVID-19 and an unfavorable outcome. The article presents a clinical observation of the course of a critical form of a new coronavirus infection in a young child with acute myeloblastic leukemia. The layering of COVID-19 contributed to a sharp deterioration of the underlying disease. Despite the highly organized treatment process with the use of modern technologies, the child had a rapid deterioration of the condition with a fatal outcome. © 2021, Dynasty Publishing House. All rights reserved.
ABSTRACT
The aim of the study was to assess the effective doses and radiation risks of children for X-ray and CT examinations during the diagnosis and treatment of COVID-19, as well as to analyze the dependence of the number of examinations and the total radiation risk for one patient on the severity of the disease. The study used the data of X-ray studies of 71 children admitted to the clinic of the St-Petersburg State Pediatric Medical University with suspicions of COVID-19, 58 children of them underwent 104 X-ray examinations, and 30 CT scans were taken for 22 children. One patient could undergo both several of the same type, as well as a combination of X-ray and CT examinations. The median values of the effective dose for X-ray chest examinations for all age groups are in the range of 0.09-0.13 mSv. The highest values are observed in the 0-4 age group. Effective doses for chest CT scan were 3.21 mSv and 4.68 mSv for groups 5-9 and 15-19 years old, respectively. For X-ray studies for women it ranges from 12.73•10-6 to 27.62•10-6, for men from 2.5•10-6 to 5.52•10-6. The minimum corresponds to the age group 10-14 years old, and the maximum - to the group 0-4 years old. For CT, the risk increases with age from 425.97•10-6 for the 5-9-year group to 434.37•10-6 for 15-19 years. The current study has not received sufficient grounds to assert that the severity of the course of the disease is associated with radiation risks from the performed CT examinations. © 2021 Author(s).
ABSTRACT
Since March 2020, the first reports have appeared about the increasing, almost everywhere, number of children who have undergone a new coronovirus infection caused by SARS-Cov-2 with a symptom complex resembling the manifestations of Kawasaki disease. A special feature of the clinical manifestations of this syndrome, which is called “Pediatric multisystem inflammatory syndrome associated with COVID-19”, is the high incidence of life-threatening conditions caused by the sharp development of arterial hypotension against the background of cardiogenic or vasogenic shock. In St. Petersburg, since the end of November 2020, there has been a sharp surge in admissions of children to the ICU of various hospitals with the clinic of Pediatric multisystem inflammatory syndrome, who have laboratory confirmation of the transferred COVID-19. The purpose of this article is to attract the attention of doctors of various profiles, to combine efforts to study this pathology, to determine the criteria for verifying the diagnosis, optimal treatment regimens and dispensary monitoring of patients who have been ill. © 2021 Interregional public organization Association of infectious disease specialists of Saint-Petersburg and Leningrad region (IPO AIDSSPbR). All rights reserved.
ABSTRACT
This summary paper presents a generalized action plan for hospitals and outpatient clinics during the COVID-19 coronavirus pandemic. Now the pandemic is the most relevant global challenge. Taking into account that the medical world does not have much clinical experience with COVID-19 and other coronaviruses, such as SARS-CoV and MERS-CoV, thoroughness and caution in assessing and treating pregnant women is an extremely urgent topic. The authors of this article summarized the world experience in managing patients with coronavirus disease and brought it into a unique algorithm that was considered most rational.